Mechanisms of actin-binding proteins in glycolysis-cytoskeleton coupling

Ziluo Zhang, Ningye Ma, Nan Zhang, Xinjia Wang, Yiwei Lu, Chengcheng Sheng, Jiantong Zhang, Xianghan Zhao, Yisheng Jiao, Aiyuan Wang · 2026

Read Mechanisms of actin-binding proteins in glycolysis-cytoskeleton coupling by Ziluo Zhang, Ningye Ma, Nan Zhang, Xinjia Wang, Yiwei Lu, Chengcheng Sheng, Jiantong Zhang, Xianghan Zhao, Yisheng Jiao, Aiyuan Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13281498.txt.

Description

Ziluo Zhang and colleagues set out a new frame for how cells link movement and fuel in a 2026 review. Each cell holds a scaffold of actin threads that gives it shape and lets it move. Cells also burn sugar for quick fuel, a process called glycolysis. The two systems talk to each other both ways. Proteins that bind the scaffold sit at the crossroads of that talk. The review pulls recent work into one model of the loop.

In their model, scaffold-binding proteins relay force signals into fuel choices. Fuel flow, in turn, feeds back to reshape the scaffold. The authors trace the signal chains step by step in several cell settings. They flag where studies clash and which questions stay open. The frame spans from outside force on a cell to its final behavior. They suggest it may guide care for cancers and scarring diseases.

Catalog record

CREATORZiluo Zhang, Ningye Ma, Nan Zhang, Xinjia Wang, Yiwei Lu, Chengcheng Sheng, Jiantong Zhang, Xianghan Zhao, Yisheng Jiao, Aiyuan Wang
YEAR2026
COLLECTIONPAPERS
FORMATTXT
FILE SIZE63915
LICENSEhttps://creativecommons.org/licenses/by/4.0
RIGHTSCC BY
SOURCEEurope PMC

Source: https://europepmc.org/article/MED/PMC13281498

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