Personalized tacrolimus therapy in allogeneic hematopoietic stem cell transplantation: from pharmacokinetic variability to novel control strategies
Naoki Yoshikawa · 2026
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Description
Naoki Yoshikawa reviews how doctors set the dose of tacrolimus for people who receive stem cell transplants from a donor. The drug guards against graft-versus-host disease, where donor cells attack the body, but too much or too little can do harm. Blood levels of the drug vary a lot from person to person, and they can shift fast as blood counts fall and then recover after treatment.
The review explains why simple blood tests can mislead in these patients. The drug clings to red and white blood cells, so cell counts change what a test seems to show. Gene traits that affect how the body breaks the drug down also play a part. Yoshikawa then looks at newer ways to tailor doses to each patient, with the aim of safer and more exact care.
Catalog record
| CREATOR | Naoki Yoshikawa |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 22 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |