An alternative inhibitory avoidance task for studying hippocampus-dependent spatial aversive memory in mice
Haiyan Wang, Masanori Nomoto, Emi Murayama, Kaori Yamada-Nomoto, Kaoru Inokuchi · 2026
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Description
Wang, Nomoto, Murayama, Yamada-Nomoto, and Inokuchi published in twenty twenty-six a new mouse task for studying fear-linked spatial memory. Animals must reach goals while avoiding danger, and route choice matters for survival. Few mouse tasks measure avoidance through choice of path. Their task first trains thirsty mice to prefer a short path to water. Then an air puff at the path's center teaches them to avoid it.
Mice given few puffs avoided weakly hours later. Mice trained until they rarely chose the short path avoided strongly a day later. Blocking hippocampus activity before testing erased the avoidance memory. The hippocampus is a brain area key for spatial memory. The task gives researchers a clean way to study how bad experiences reshape route choice.
Catalog record
| CREATOR | Haiyan Wang, Masanori Nomoto, Emi Murayama, Kaori Yamada-Nomoto, Kaoru Inokuchi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 17 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |