Investigating the versatility of cytochalasan cytochrome P450 monooxygenases using combinatorial biosynthesis reveals stereochemical restrictions
Lei Li, Tahir Ali, Jacob Goralczyk, Sameera Jayasundara, Ayan Paul, Marcelo Rodrigues de Amorim, Christine Beemelmanns, Elizabeth Skellam · 2026
Read Investigating the versatility of cytochalasan cytochrome P450 monooxygenases using combinatorial biosynthesis reveals stereochemical restrictions by Lei Li, Tahir Ali, Jacob Goralczyk, Sameera Jayasundara, Ayan Paul, Marcelo Rodrigues de Amorim, Christine Beemelmanns, Elizabeth Skellam (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13281438.txt.
Description
Lei Li and colleagues probed fungus enzymes that tailor natural poisons in a 2026 study. The poisons, called cytochalasans, freeze a cell's inner scaffold and affect many living things. Fungi build them with help from enzymes that add oxygen at set spots. Those enzymes are picky at home yet can accept near kin of their usual targets. The team mined gene maps of six fungi for hidden build plans. They then placed seven enzymes into a test fungus.
Three enzymes could be pinned to clear jobs, two never described before. Shape rules in the target, down to left- or right-handed twists, decided whether an enzyme could act. The work shows why some enzymes sat idle on the targets at hand. The authors say the mix-and-match method can scout enzymes as tools for green chemistry. It also helps read what new poisons a fungus might make.
Catalog record
| CREATOR | Lei Li, Tahir Ali, Jacob Goralczyk, Sameera Jayasundara, Ayan Paul, Marcelo Rodrigues de Amorim, Christine Beemelmanns, Elizabeth Skellam |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36665 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |