Serotonin 5-HT7 receptor signaling modulates inflammatory responses and survival after myocardial infarction
Franziska E Müller, Frauke S Bahr, Sergej Erschow, Martina Kasten, Maren Heimerl, Nils Benen, Mira Jung, Arne Schmidt, Michaela Scherr, Christine S Falk, Christian Bustamante, Igor Ponomarev, Johann Bauersachs, Denise Hilfiker-Kleiner, Thomas Thum, Evgeni G Ponimaskin, Melanie Ricke-Hoch · 2026
Read Serotonin 5-HT7 receptor signaling modulates inflammatory responses and survival after myocardial infarction by Franziska E Müller, Frauke S Bahr, Sergej Erschow, Martina Kasten, Maren Heimerl, Nils Benen, Mira Jung, Arne Schmidt, Michaela Scherr, Christine S Falk, Christian Bustamante, Igor Ponomarev, Johann Bauersachs, Denise Hilfiker-Kleiner, Thomas Thum, Evgeni G Ponimaskin, Melanie Ricke-Hoch (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13281426.txt.
Description
Franziska E Müller and colleagues studied a serotonin switch in heart attack repair in a 2026 paper. Serotonin is best known for mood, but it also steers immune cells. After a heart attack, swelling must be tuned well for the heart to heal. The team blocked a heart artery in mice and read the damaged zone. They also checked blood cells from human heart attack patients. A serotonin receptor, a switch on cells, spiked in the wound in the first days.
The switch was rich on macrophages, the immune cells that clean wounds. Mice bred without the switch had weaker hearts two weeks on, with more swelling. A drug that turns the switch on helped more mice live, though heart strength in survivors did not rise. Two gene markers shifted with the switch in both mice and patients. The authors name the switch a tuning knob for post-attack swelling.
Catalog record
| CREATOR | Franziska E Müller, Frauke S Bahr, Sergej Erschow, Martina Kasten, Maren Heimerl, Nils Benen, Mira Jung, Arne Schmidt, Michaela Scherr, Christine S Falk, Christian Bustamante, Igor Ponomarev, Johann Bauersachs, Denise Hilfiker-Kleiner, Thomas Thum, Evgeni G Ponimaskin, Melanie Ricke-Hoch |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56353 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |