A Systematic Review of Literature: TNF‐α Blockers and JAK Inhibitors for the Treatment of Stevens‐Johnson Syndrome, Toxic Epidermal Necrolysis, and Severe Forms of Erythema Multiforme
Sadaf Salehi, Pooneh Torabi, Mahsa Abbaspour, Nima Hajizadeh, Sara Sadeghi, Alireza Jafarzadeh, Azadeh Goodarzi · 2026
Read A Systematic Review of Literature: TNF‐α Blockers and JAK Inhibitors for the Treatment of Stevens‐Johnson Syndrome, Toxic Epidermal Necrolysis, and Severe Forms of Erythema Multiforme by Sadaf Salehi, Pooneh Torabi, Mahsa Abbaspour, Nima Hajizadeh, Sara Sadeghi, Alireza Jafarzadeh, Azadeh Goodarzi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13281412.txt.
Description
Sadaf Salehi and colleagues reviewed two drug families for severe skin reactions in a 2026 paper. The reactions can peel skin and harm the mouth and eyes, and they can kill. They are often set off by drugs or infections. Standard care is slow, so new immune-calming drugs have been tried. The review gathered eighty-two papers with more than seven hundred patients in all. It covered case reports, group studies, and trials up to late 2025.
Some patients healed fast on the new drugs, with skin closing sooner and sores easing. Drugs that block one swelling signal looked hopeful for patients whom standard care had failed. The review links them to shorter illness, shorter hospital stays, and fewer deaths. Drugs that block a cell switchboard showed promise too. The authors still urge care, since much of the proof rests on single cases.
Catalog record
| CREATOR | Sadaf Salehi, Pooneh Torabi, Mahsa Abbaspour, Nima Hajizadeh, Sara Sadeghi, Alireza Jafarzadeh, Azadeh Goodarzi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 73514 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |