Triarylselenonium triflates provide efficient access to no-carrier-added ortho-, meta-, and para-[18F]Fluoroarenes
Jake Sypniewski, Yong-Sok Lee, Phuc Tran, Sean Costner, Fabrice G. Siméon, Victor W. Pike · 2026
Read Triarylselenonium triflates provide efficient access to no-carrier-added ortho-, meta-, and para-[18F]Fluoroarenes by Jake Sypniewski, Yong-Sok Lee, Phuc Tran, Sean Costner, Fabrice G. Siméon, Victor W. Pike (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13280978.txt.
Description
Jake Sypniewski and colleagues reported a new chemistry route to imaging tracers in a 2026 study. Doctors scan the body with tracers that carry a short-lived form of fluorine. The tracers must be made fast and pure, since the fluorine fades in about two hours. The team made a family of salts based on selenium, a chemical cousin of sulfur. They tested how well each salt handed its fluorine slot to the tracer form.
Many salts gave high yields of the wanted tracers, above seven in ten tries. Some weaker salts still gave useful yields. Helper groups on the salt pushed some yields close to full. In direct tests the selenium salts matched or beat the sulfur salts used now. The team also built two known tracers this way. They say the route widens the menu of scans doctors can order.
Catalog record
| CREATOR | Jake Sypniewski, Yong-Sok Lee, Phuc Tran, Sean Costner, Fabrice G. Siméon, Victor W. Pike |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48701 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |