Evidence for the Formation of Metabolons Surrounding the Pyruvate Node in the Supercritical CO2‑Tolerant Priestia megaterium SR7
Nathaphon Yu King Hing, Yi Wen Kristy Chang, Ramanujam Srinivasan Vethathirri, Yulan Wang, Janelle R. Thompson · 2026
Read Evidence for the Formation of Metabolons Surrounding the Pyruvate Node in the Supercritical CO2‑Tolerant Priestia megaterium SR7 by Nathaphon Yu King Hing, Yi Wen Kristy Chang, Ramanujam Srinivasan Vethathirri, Yulan Wang, Janelle R. Thompson (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13280911.txt.
Description
Nathaphon Yu King Hing and colleagues published a 2026 study showing enzymes in a carbon-dioxide-proof bacterium organize into metabolons, complexes that pass molecules from one enzyme to the next. The bacterium, Priestia megaterium SR7, lives in supercritical carbon dioxide, an extreme valued by carbon-fixing engineers. The team focused on the pyruvate node, the hub where carbon traffic splits among energy production, replenishment, and building blocks.
Cross-linking followed by protein tests caught four enzymes around that hub interacting in the test tube, including pyruvate kinase and lactate dehydrogenase. Computer models of the pairs suggested likely contact faces. Carbon-13 labeling tests in living cells showed metabolite pools thinning as expected if compounds are channeled inside complexes rather than released into the cell. The authors argue this grouping is a real layer in its central metabolism. If confirmed, such complexes could help route carbon better in industrial strains.
Catalog record
| CREATOR | Nathaphon Yu King Hing, Yi Wen Kristy Chang, Ramanujam Srinivasan Vethathirri, Yulan Wang, Janelle R. Thompson |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |