A Validated LC–MS/MS Method for the Determination of Perospirone in Human Plasma and Its Pharmacokinetic Application in Healthy Volunteers
Benkai Qin, Huina Zhang, Hangyu Zhao, Yuchen Su, Yifu Kong, Shengshuo Zhang, Luwei Wang, Yonghua Yu, Jie Gu, Tingting Lou · 2026
Read A Validated LC–MS/MS Method for the Determination of Perospirone in Human Plasma and Its Pharmacokinetic Application in Healthy Volunteers by Benkai Qin, Huina Zhang, Hangyu Zhao, Yuchen Su, Yifu Kong, Shengshuo Zhang, Luwei Wang, Yonghua Yu, Jie Gu, Tingting Lou (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13280890.txt.
Description
Benkai Qin and colleagues published a 2026 methods paper on a fast blood test for perospirone, an atypical antipsychotic used for schizophrenia that acts on dopamine and serotonin receptors. Measuring the drug in plasma supports dose tuning and bioequivalence studies, yet a reliable assay had to be demonstrated. Their liquid chromatography and tandem mass spectrometry method uses a deuterium-labeled drug version as an internal standard. It separates compounds on a column in minutes and detects the drug by its fragment pattern.
The assay stayed linear across a range, from 0.0200 to 12.0 nanograms per milliliter, covering the levels expected. Checks for specificity, sensitivity, and stability passed. The team then applied the method to pharmacokinetic studies in healthy volunteers who took the tablets fasting and after food. The authors present the validated procedure as ready for such studies, equivalence tests between formulations, and therapeutic drug monitoring. Precise levels guide care there.
Catalog record
| CREATOR | Benkai Qin, Huina Zhang, Hangyu Zhao, Yuchen Su, Yifu Kong, Shengshuo Zhang, Luwei Wang, Yonghua Yu, Jie Gu, Tingting Lou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |