Overcoming Biological Barriers: A Comprehensive Review of Advanced Melatonin Delivery Systems for Therapeutic Applications
Zhenyu Yang, Yiduo Chen, Shaoying Li, Xiaoyue Lei, Xincheng Wu, Yuan Wang, Shuli Deng · 2026
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Description
Zhenyu Yang and colleagues wrote a 2026 review on better ways to deliver melatonin, the sleep hormone. Melatonin can fight cell damage and swelling and may help many diseases. But it dissolves poorly in water and the liver breaks it down fast. Little of a swallowed dose reaches where it is needed. Walls in the brain, skin, and gut block it as well.
The review covers tiny carriers built to slip past those walls. It explains how carrier design fits each route, such as by mouth, skin, or nose. It sums up lab tests in models of brain disease, heart attack, eye disease, low mood, and cancer. The authors close with blocks to clinic use, such as making the carriers at scale and proving long-term safety.
Catalog record
| CREATOR | Zhenyu Yang, Yiduo Chen, Shaoying Li, Xiaoyue Lei, Xincheng Wu, Yuan Wang, Shuli Deng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 91102 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |