Nanostructure and Collagen‐Stimulating Activity of Cationic Pentapeptide Lipopeptides
Lucas R. de Mello, Valeria Castelletto, Jani Seitsonen, Ian W. Hamley · 2026
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Description
De Mello and co-authors compare two fat-tailed peptides used in skin care. Their 2026 paper studies C16-KTTKS, sold commercially as Matrixyl, and a variant called C16-RTTRS in which one building block is swapped. Both molecules are reported to boost collagen, the protein that firms skin, but their assembly in water was less clear.
The authors measured how each peptide arranges itself across acidity levels and in two salt forms. The original peptide formed flat nanotapes across most conditions and round micelles only in strong acid, while the variant switched shapes depending on its salt partner. Both peptides were gentle on fibroblast cells at low doses. Each also stimulated collagen production in human skin fibroblasts at very low concentration, with no clear difference between salt forms.
Catalog record
| CREATOR | Lucas R. de Mello, Valeria Castelletto, Jani Seitsonen, Ian W. Hamley |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |