Exosome‐Related Gene Signature Predicts Prognosis and Immunotherapy in Gastric Cancer
Qunru Jiao, Rui Zhang, Yingyun Guo, Xiulan Peng, Longshu Zhou · 2026
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Description
Qunru Jiao and colleagues report a 2026 study that builds an exosome related gene signature for gastric cancer prognosis. Exosomes are tiny parcels shed by cells that play a crucial role in tumour progression. Reliable exosome biomarkers for prognosis in gastric cancer remain scarce. RNA data from exoRbase and TCGA datasets were mined for exosome genes linked to survival. A multivariate Cox model built the risk signature and a prognostic nomogram, a scoring chart.
Four exosome related genes emerged as independent prognostic factors: TRAF2, ASCL2, NOX4 and MMRN1. Patients with low risk scores showed significantly better survival outcomes. Kaplan Meier and ROC curve analyses tested the signature in training and validation datasets. Links with clinical features, copy number variation and immunotherapy sensitivity were explored as well. Protein blots validated key gene levels in gastric cancer tissues. The four gene score could stratify care.
Catalog record
| CREATOR | Qunru Jiao, Rui Zhang, Yingyun Guo, Xiulan Peng, Longshu Zhou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38038 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |