CL-316243 facilitates stable atherosclerotic plaque phenotypes in association with suppression of perivascular adipose tissue ferroptosis via upregulating C/EBPβ
Yuanqing Jiang, Yi Li, Kefan Ma, Suxiang Guo, Nachuan Liao, Jiayi Zhou, Junbo Chen, Ruizhe Ren, Yaohui Kou, Jinying Li, He Liu, Yang Wei, Xiaofei Zhou, Linge Fan, Lingfeng Qin, Haige Zhao, Ying Xiao, Luyang Yu, Zhen Ge, Cong Qiu · 2026
Read CL-316243 facilitates stable atherosclerotic plaque phenotypes in association with suppression of perivascular adipose tissue ferroptosis via upregulating C/EBPβ by Yuanqing Jiang, Yi Li, Kefan Ma, Suxiang Guo, Nachuan Liao, Jiayi Zhou, Junbo Chen, Ruizhe Ren, Yaohui Kou, Jinying Li, He Liu, Yang Wei, Xiaofei Zhou, Linge Fan, Lingfeng Qin, Haige Zhao, Ying Xiao, Luyang Yu, Zhen Ge, Cong Qiu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13279912.txt.
Description
Yuanqing Jiang and colleagues report a 2026 study of plaque stability and fat round arteries. Plaque rupture, where a fatty wall deposit breaks, causes most heart attacks and strokes. Fat tissue round vessels, called PVAT, can go wrong and weaken plaques. The team find ferroptosis, an iron driven cell death, as a key flaw in that fat in artery disease. A drug called CL-316243, which wakes a fat receptor, is their test tool.
The drug curbed ferroptosis marks in fat cells in dishes and in fat round diseased arteries. It also cut fat swelling and flaw, by tissue, gene and function checks. Plaques grew more stable in form, with smaller dead cores. A gene switch called C/EBP beta rose with the drug and tied the chain. Guarding vessel fat from iron death may steady plaques.
Catalog record
| CREATOR | Yuanqing Jiang, Yi Li, Kefan Ma, Suxiang Guo, Nachuan Liao, Jiayi Zhou, Junbo Chen, Ruizhe Ren, Yaohui Kou, Jinying Li, He Liu, Yang Wei, Xiaofei Zhou, Linge Fan, Lingfeng Qin, Haige Zhao, Ying Xiao, Luyang Yu, Zhen Ge, Cong Qiu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 91593 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |