BCL2 promoter region mutations are an independent marker of BCL2 level in lymphoid malignancies
Daniel Kuznicki, Paulina Galka-Marciniak, Malwina Suszynska, Piotr Kozlowski · 2026
Read BCL2 promoter region mutations are an independent marker of BCL2 level in lymphoid malignancies by Daniel Kuznicki, Paulina Galka-Marciniak, Malwina Suszynska, Piotr Kozlowski (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13279811.txt.
Description
Daniel Kuznicki and colleagues report a 2026 study of gene control faults in the BCL2 gene in lymphoid cancers. BCL2 upregulation, or raised gene output, drives lymphoma growth and shapes drug response. Past models blamed a chromosome swap or loss of small RNA brakes. Faults in the gene promoter, the control zone before the gene, were little explored. Noncoding zones are hard to read and often skipped in genome scans.
Large genome sets showed a lymphoma specific hotspot of faults in the BCL2 promoter. The faults linked to raised output from one gene copy alone, apart from the chromosome swap. They break protein binding sites in the control zone and shift gene form balance. In diffuse large B cell lymphoma, they also linked to worse survival. Promoter faults stand as an independent marker of BCL2 level for care calls.
Catalog record
| CREATOR | Daniel Kuznicki, Paulina Galka-Marciniak, Malwina Suszynska, Piotr Kozlowski |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 22977 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |