Polyfunctional antibody signature defines protection in Andes hantavirus survival
Felipe Bravo, Tybbysay P. Salinas, Camila Kossack, Jorge T. Gonzalez, Israel Giacaman, Claudio Quevedo, Sebastián Fuller, Farides Saavedra, Claudio Aguilera-Pérez, Felipe Aguilera, Raúl Riquelme, María Luisa Rioseco, Mario Calvo, Raymond A. Alvarez, Juan Miguel Pascale, Blas Armién, Maritza Navarret · 2026
Read Polyfunctional antibody signature defines protection in Andes hantavirus survival by Felipe Bravo, Tybbysay P. Salinas, Camila Kossack, Jorge T. Gonzalez, Israel Giacaman, Claudio Quevedo, Sebastián Fuller, Farides Saavedra, Claudio Aguilera-Pérez, Felipe Aguilera, Raúl Riquelme, María Luisa Rioseco, Mario Calvo, Raymond A. Alvarez, Juan Miguel Pascale, Blas Armién, Maritza Navarret (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13279636.txt.
Description
Felipe Bravo and colleagues published a 2026 immunology study of what sets survivors of Andes hantavirus apart. The virus causes severe lung and heart syndrome, with mortality around 30 to 40 percent. Neutralizing antibodies were already known to matter. The team asked what the antibodies' Fc tails do, since those parts recruit immune cells and complement proteins. They profiled blood from acute patients and long-term survivors, testing antibody types and Fc-driven functions.
Patients whose illness stayed moderate carried higher IgG against one surface protein. They also showed stronger Fc activity, including natural killer cell activation and complement deposition, than severe patients. Survivors showed raised IgG and IgM against the same target. Years later, survivors still carried antibodies that did several Fc jobs at once, though they did not neutralize the virus in a dish. The authors argue vaccine and therapy design should aim for this broader profile, not neutralization alone.
Catalog record
| CREATOR | Felipe Bravo, Tybbysay P. Salinas, Camila Kossack, Jorge T. Gonzalez, Israel Giacaman, Claudio Quevedo, Sebastián Fuller, Farides Saavedra, Claudio Aguilera-Pérez, Felipe Aguilera, Raúl Riquelme, María Luisa Rioseco, Mario Calvo, Raymond A. Alvarez, Juan Miguel Pascale, Blas Armién, Maritza Navarret |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |