Hemoglobin-to-Red cell distribution width ratio and asthma risk: cross-population validation and vitamin D mediation analysis
Yanbiao Xiao, Jun Lai, Yanglin Zhang · 2026
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Description
Yanbiao Xiao and colleagues published a 2026 study of a simple blood ratio and asthma risk across two populations. The ratio divides hemoglobin by red cell distribution width, which measures how much red cells vary in size. The team analyzed 19,140 participants from the United States NHANES surveys. They checked the association again in 519 patients from a hospital in Ganzhou, China, also asking whether vitamin D levels carry the effect.
In the American data, a higher ratio was tied to lower asthma odds, with adjusted odds of 0.60 per unit. Vitamin D accounted for the whole association. The Chinese cohort showed the same inverse direction with a stronger estimate. Its predictive accuracy alone was modest at best, and the authors stress it is no stand-alone diagnostic test. They position it as a cheap, routine component inside broader risk models, pending an explanation of why vitamin D sits in the middle.
Catalog record
| CREATOR | Yanbiao Xiao, Jun Lai, Yanglin Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |