Peripheral Circulating Exosomes Induce Sepsis-associated Liver Injury by Up-regulating STAT1 to Promote Autophagy and Regulating the SLC7A11-GSH-GPX4 Axis to Promote Ferroptosis
Yu-Jia Tang, Xue Du, Bing Yin, Hui-Ying Liu, Yi-Jin Tang, Zi-Yue Zhang, Qing-Min Meng, Yan Zhang, Jia-Le Deng, Yao Li, Pei-Lin Yang, Kai Kang, Ming-Yan Zhao, Yang Gao · 2026
Read Peripheral Circulating Exosomes Induce Sepsis-associated Liver Injury by Up-regulating STAT1 to Promote Autophagy and Regulating the SLC7A11-GSH-GPX4 Axis to Promote Ferroptosis by Yu-Jia Tang, Xue Du, Bing Yin, Hui-Ying Liu, Yi-Jin Tang, Zi-Yue Zhang, Qing-Min Meng, Yan Zhang, Jia-Le Deng, Yao Li, Pei-Lin Yang, Kai Kang, Ming-Yan Zhao, Yang Gao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13279614.txt.
Description
Yu-Jia Tang and co-authors show how blood borne parcels from septic mice wound the liver. Sepsis often fails several organs at once. The parcels, tiny exosomes, were fed to liver cells and injected into mice. Gene scans pointed to a master switch, STAT1, as the parcels' lever.
With that switch raised, liver cells self digested more and slid into an iron driven death called ferroptosis. Their defenses on a known axis sagged. Blocking the switch erased the harm; boosting it worsened things. In living mice, septic parcels injured the liver unless the switch was suppressed. The authors name a fresh target for sepsis care.
Catalog record
| CREATOR | Yu-Jia Tang, Xue Du, Bing Yin, Hui-Ying Liu, Yi-Jin Tang, Zi-Yue Zhang, Qing-Min Meng, Yan Zhang, Jia-Le Deng, Yao Li, Pei-Lin Yang, Kai Kang, Ming-Yan Zhao, Yang Gao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |