Long-range mutual activation establishes Rho and Rac polarity during cell migration
Henry De Belly, Andreu F. Gallén, Evelyn Strickland, Dorothy C. Estrada, David Sanchez Godinez, Eric Neiva, Patrick J. Zager, Tamas L. Nagy, Janis K. Burkhardt, Hervé Turlier, Orion D. Weiner · 2026
Read Long-range mutual activation establishes Rho and Rac polarity during cell migration by Henry De Belly, Andreu F. Gallén, Evelyn Strickland, Dorothy C. Estrada, David Sanchez Godinez, Eric Neiva, Patrick J. Zager, Tamas L. Nagy, Janis K. Burkhardt, Hervé Turlier, Orion D. Weiner (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13279283.txt.
Description
Henry De Belly and colleagues report a 2026 study of how moving cells set a front and a back. Two switch proteins run the split: Rac builds the push front, while Rho runs the squeeze back. How they land at far poles was unclear. The team used light based cell controls, force probes and math models to trace the talk between poles.
Push at the front raised skin tension, which woke Rho at the far back through a growth control path. Squeeze at the back drove flow in the cell skin that woke Rac at the far front. Near by, each switch still blocks the other. Far reach help plus near block gives a firm split. The circuit held in human immune T cells and skin like cells, and drove sound cell travel.
Catalog record
| CREATOR | Henry De Belly, Andreu F. Gallén, Evelyn Strickland, Dorothy C. Estrada, David Sanchez Godinez, Eric Neiva, Patrick J. Zager, Tamas L. Nagy, Janis K. Burkhardt, Hervé Turlier, Orion D. Weiner |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 108338 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |