Successful salvage treatment of Mucor nidicola and Aspergillus calidoustus co-infection with oral encochleated amphotericin B (MAT2203) in a pediatric patient with acute myeloid leukemia
Christopher P. Ouellette, Monica I. Ardura, Connie Gibas, Nathan Wiederhold, Eunkyung Song · 2026
Read Successful salvage treatment of Mucor nidicola and Aspergillus calidoustus co-infection with oral encochleated amphotericin B (MAT2203) in a pediatric patient with acute myeloid leukemia by Christopher P. Ouellette, Monica I. Ardura, Connie Gibas, Nathan Wiederhold, Eunkyung Song (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13279205.txt.
Description
Christopher P Ouellette and colleagues published a 2026 case report of a teenager with acute myeloid leukemia who survived a dangerous double fungal infection thanks to an oral form of amphotericin B. The 15-year-old developed sinus and lung infection with two molds, Mucor nidicola and Aspergillus calidoustus, three weeks after intensive chemotherapy had left her white cell counts near zero. The Aspergillus strain had limited susceptibility to azole drugs, the usual oral option.
Standard intravenous liposomal amphotericin B caused toxicity, so the team switched to MAT2203, an encochleated form that wraps the drug in lipid layers so it can be swallowed. The infection, which had spared the eyes and brain, was successfully treated. The report matters because invasive mold infections in children with leukemia are often fatal. An effective oral salvage option could spare patients weeks of intravenous therapy and its side effects.
Catalog record
| CREATOR | Christopher P. Ouellette, Monica I. Ardura, Connie Gibas, Nathan Wiederhold, Eunkyung Song |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 12 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |