Protein Arginine Methyltransferase 6 Regulated Odontogenic Differentiation and Mitochondrial Function of Stem Cells from Apical Papilla Through its Nuclear Localization Sequence via β-catenin Pathway
Wanhao Yan, Xiaoli Guo, Bingqi Zhao, Yongkang Li, Zhe Shen, Ruitang Shi, Chen Zhang · 2026
Read Protein Arginine Methyltransferase 6 Regulated Odontogenic Differentiation and Mitochondrial Function of Stem Cells from Apical Papilla Through its Nuclear Localization Sequence via β-catenin Pathway by Wanhao Yan, Xiaoli Guo, Bingqi Zhao, Yongkang Li, Zhe Shen, Ruitang Shi, Chen Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13279183.txt.
Description
Wanhao Yan and colleagues report a 2026 study of stem cells from the tip of young tooth roots. These cells, called stem cells from apical papilla, can form tooth like tissue. That trait makes them key for pulp regeneration, meaning regrowth of the soft core of teeth. The team asks how a protein called PRMT6 guides their growth.
Cell tests used normal PRMT6 and a form that lacks its nuclear entry tag. The tag helps the protein enter the cell nucleus, its control centre. Growth tests, stains and mouse grafts tracked tooth and bone formation. Power tests checked cell energy health. A gene pathway centred on beta catenin, a growth signal protein, linked the tag to cell fate. Blocking that pathway in rescue tests helped prove the link.
Catalog record
| CREATOR | Wanhao Yan, Xiaoli Guo, Bingqi Zhao, Yongkang Li, Zhe Shen, Ruitang Shi, Chen Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59821 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |