Obstructive Sleep Apnea Treatment Modifies the Effectiveness of Catheter Ablation for Atrial Fibrillation: Post Hoc Analysis of the CABANA Trial
Matthew W Segar, Kaleb D Lambeth, Brett Doliner, Joshua R Hirsch, Abdi Rasekh, Mehdi Razavi · 2026
Read Obstructive Sleep Apnea Treatment Modifies the Effectiveness of Catheter Ablation for Atrial Fibrillation: Post Hoc Analysis of the CABANA Trial by Matthew W Segar, Kaleb D Lambeth, Brett Doliner, Joshua R Hirsch, Abdi Rasekh, Mehdi Razavi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13279133.txt.
Description
Matthew Segar and five co-authors reanalyzed a major heart rhythm trial in 2026. The CABANA trial randomized 2,204 patients with atrial fibrillation to catheter ablation or drug therapy. About half of such patients also have obstructive sleep apnea, where breathing stops during sleep. Untreated apnea may blunt ablation success, but trial proof was missing. This post hoc analysis filled that gap.
The team split 2,203 patients by apnea status and by treatment, such as CPAP machines or oral devices, drawn from records and patient reports. The outcome was return of the abnormal rhythm. The paper's title states the conclusion: apnea treatment status changes how well ablation works. The work was prespecified as a question in the original trial plan.
Catalog record
| CREATOR | Matthew W Segar, Kaleb D Lambeth, Brett Doliner, Joshua R Hirsch, Abdi Rasekh, Mehdi Razavi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 10 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |