Targeting Inflammation by Pioglitazone and its R-Enantiomer Mitigates Pathological Myocardial Remodeling in Murine Hypertrophic Cardiomyopathy
Anna-Theresa Pfaller, Claudia Veneziano, Sarala Raj Murthi, Jan B. Stöckl, Bachuki Shashikadze, Florian Flenkenthaler, Josh Gorham, Alessandra Moretti, Ana Kitanovic, Linden J. Gearing, Frederik Heinrich, Pawel Durek, Katrin Lehmann, Mir-Farzin Mashreghi, Peter Ewert, Thomas Fröhlich, Joachim P. Schmitt, Nadine Spielmann, Martin Hrabě de Angelis, Manuel Schmid, Christopher N. Toepfer, Eicke Latz, Karin Klingel, Gianluca Santamaria, Jonathan G. Seidman, Christine E. Seidman, Cordula M. Wolf · 2026
Read Targeting Inflammation by Pioglitazone and its R-Enantiomer Mitigates Pathological Myocardial Remodeling in Murine Hypertrophic Cardiomyopathy by Anna-Theresa Pfaller, Claudia Veneziano, Sarala Raj Murthi, Jan B. Stöckl, Bachuki Shashikadze, Florian Flenkenthaler, Josh Gorham, Alessandra Moretti, Ana Kitanovic, Linden J. Gearing, Frederik Heinrich, Pawel Durek, Katrin Lehmann, Mir-Farzin Mashreghi, Peter Ewert, Thomas Fröhlich, Joachim P. Schmitt, Nadine Spielmann, Martin Hrabě de Angelis, Manuel Schmid, Christopher N. Toepfer, Eicke Latz, Karin Klingel, Gianluca Santamaria, Jonathan G. Seidman, Christine E. Seidman, Cordula M. Wolf (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13279018.txt.
Description
Anna-Theresa Pfaller and a large team report a 2026 study of a heart muscle illness in mice. The illness is hypertrophic cardiomyopathy, where heart walls grow thick and stiff. It affects about one in five hundred people and is a top cause of sudden death in the young. The team tests whether a drug called pioglitazone, and its R form, can calm swelling and curb bad heart change.
Early pages set out why thick walls may stem from high energy use, worn power parts in cells and swelling that scars the heart. The study uses a mouse line that carries a common human gene fault for the illness. Those mice grow thick walls and scars by about thirty weeks of age, giving a test bed for the drug.
Catalog record
| CREATOR | Anna-Theresa Pfaller, Claudia Veneziano, Sarala Raj Murthi, Jan B. Stöckl, Bachuki Shashikadze, Florian Flenkenthaler, Josh Gorham, Alessandra Moretti, Ana Kitanovic, Linden J. Gearing, Frederik Heinrich, Pawel Durek, Katrin Lehmann, Mir-Farzin Mashreghi, Peter Ewert, Thomas Fröhlich, Joachim P. Schmitt, Nadine Spielmann, Martin Hrabě de Angelis, Manuel Schmid, Christopher N. Toepfer, Eicke Latz, Karin Klingel, Gianluca Santamaria, Jonathan G. Seidman, Christine E. Seidman, Cordula M. Wolf |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53059 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |