Decoding type 5 diabetes using spatial omics: microarchitectural and molecular mechanisms of malnutrition-associated diabetes
Anusha Komati, Kiranmai Mandava, Ajay Anand · 2026
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Description
Anusha Komati and colleagues published a 2026 review arguing that malnutrition-related diabetes deserves formal recognition as type 5 diabetes. The condition affects lean people in low- and middle-income countries who experienced undernutrition early in life. Unlike type 2 diabetes, it mainly weakens insulin release while the body still responds to insulin.
Drawing on population and molecular studies, the authors describe altered structure inside pancreatic islets, gene-control changes laid down by early malnutrition, and disturbed gut bacteria. New spatial omics tools, which map gene activity within intact tissue, now reveal region-specific changes in the pancreas. The review calls for clear rules for spotting the disease and a dedicated global working group. It also wants care plans suited to poor settings, so an overlooked patient group can be properly identified and treated.
Catalog record
| CREATOR | Anusha Komati, Kiranmai Mandava, Ajay Anand |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 81 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |