Human microglial transitions at the Aβ–tau inflection point associate with divergent pathways to dementia and resilience
Ashley Lu, Wei-Ting Chen, Maria Dalby, Diego Sainz Garcia, Marisa Vanheusden, Luuk E. de Vries, Veerle van Lieshout, Araks Martirosyan, Katleen Craessaerts, Sebastiaan Moonen, Magdalena Zielonka, Iordana Chrysidou, Anke Misbaer, Leen Wolfs, Benjamin Pavie, Dick Swaab, Dietmar Rudolf Thal, Inge Huiti · 2026
Read Human microglial transitions at the Aβ–tau inflection point associate with divergent pathways to dementia and resilience by Ashley Lu, Wei-Ting Chen, Maria Dalby, Diego Sainz Garcia, Marisa Vanheusden, Luuk E. de Vries, Veerle van Lieshout, Araks Martirosyan, Katleen Craessaerts, Sebastiaan Moonen, Magdalena Zielonka, Iordana Chrysidou, Anke Misbaer, Leen Wolfs, Benjamin Pavie, Dick Swaab, Dietmar Rudolf Thal, Inge Huiti (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13278961.txt.
Description
Ashley Lu and a large team map microglial cell states in ageing human brains in a 2026 Alzheimer study. Dementia is not inevitable even when amyloid and tau proteins accumulate. Brain tissue came from octogenarians with and without dementia, plus cognitively intact centenarians carrying similar amyloid loads.
Spatial and single-nucleus gene profiling charted six tissue zones forming a disease continuum. A turning point appeared where amyloid-linked inflammation gave way to tau-linked programmes. Microglia shifted there from early inflammatory states to later antigen-presenting ones. People without dementia lacked the late programme, while centenarians showed it detached from tau build-up. The transition is proposed as a resilience lever for therapy.
Catalog record
| CREATOR | Ashley Lu, Wei-Ting Chen, Maria Dalby, Diego Sainz Garcia, Marisa Vanheusden, Luuk E. de Vries, Veerle van Lieshout, Araks Martirosyan, Katleen Craessaerts, Sebastiaan Moonen, Magdalena Zielonka, Iordana Chrysidou, Anke Misbaer, Leen Wolfs, Benjamin Pavie, Dick Swaab, Dietmar Rudolf Thal, Inge Huiti |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 107 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |