SEMA4A signaling in macrophage subpopulations and its implication in osteoarthritis
Yue Qiu, Shuzhong Huang, Bo Yu, Baochen Wei, Tianyu Ren, Xiaofan Yang, Zhanying Shi, Zhaolan Wei · 2026
Read SEMA4A signaling in macrophage subpopulations and its implication in osteoarthritis by Yue Qiu, Shuzhong Huang, Bo Yu, Baochen Wei, Tianyu Ren, Xiaofan Yang, Zhanying Shi, Zhaolan Wei (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13278899.txt.
Description
Yue Qiu and colleagues trace a signalling gene between macrophage types in osteoarthritis, in a 2026 single-cell study. Joint inflammation in osteoarthritis is driven partly by the balance between attack-style M1 and repair-style M2 macrophages. Which signals coordinate their conversation was unclear.
Single-cell data from six healthy and twelve diseased joint samples were analysed for cell types and communication routes. The two macrophage groups signalled strongly to each other in both directions. Only one gene, SEMA4A, surfaced across every layer of the analysis. Its pathway peaked mid-way through macrophage state changes, with M1 cells as the main senders. The partner receptor pair SEMA4A to PLXNB2 dominated the traffic.
Catalog record
| CREATOR | Yue Qiu, Shuzhong Huang, Bo Yu, Baochen Wei, Tianyu Ren, Xiaofan Yang, Zhanying Shi, Zhaolan Wei |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |