NAT10 as a central node in cancer biology: integrating epitranscriptomic regulation, metabolic reprogramming, and immune modulation
Wentao Bo, Ying Yi, Biao Zhao, Hang Dong · 2026
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Description
Wentao Bo, Ying Yi, Biao Zhao, and Hang Dong review an RNA-modifying enzyme called NAT10 in cancer, in a 2026 article. NAT10 is the only known writer of a chemical tag, ac4C, placed on RNA molecules. Tumours lean on it to survive low oxygen, nutrient stress, and treatment attack.
Tagging stabilises key RNA messages and boosts their protein output, reinforcing growth signals. Downstream effects reach sugar metabolism, DNA repair, drug pumping, vessel growth, and immune suppression. Feedback loops with major cancer pathways lock those stress responses into permanent adaptations. Blocking NAT10 is proposed as a way to break resistance to chemotherapy and immunotherapy. Open questions cover its partner proteins and context-specific behaviour.
Catalog record
| CREATOR | Wentao Bo, Ying Yi, Biao Zhao, Hang Dong |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 77 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |