Pitaya‑inspired compartmentalized microspheres with natural tannic acid-copper coating orchestrate smart release of ions and multi-drugs for synergistic treatment of infected bone defects
Dongbiao Chang, Zhenfan Bai, Linke Li, Jun Sheng, Hongzhi Fang, Zian Wang, Zili Guo, Hui Zhang, Xinxi Yang, Rui Chen, Huan Tan, Mengyuan Wang, Jie Weng · 2026
Read Pitaya‑inspired compartmentalized microspheres with natural tannic acid-copper coating orchestrate smart release of ions and multi-drugs for synergistic treatment of infected bone defects by Dongbiao Chang, Zhenfan Bai, Linke Li, Jun Sheng, Hongzhi Fang, Zian Wang, Zili Guo, Hui Zhang, Xinxi Yang, Rui Chen, Huan Tan, Mengyuan Wang, Jie Weng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13278850.txt.
Description
Dongbiao Chang and colleagues build drug-releasing microspheres shaped like pitaya fruit for infected bone defects, in a 2026 study. Infected bone wounds turn acidic, harbour stubborn bacteria, and heal poorly. Their spheres carry copper ions, an antibiotic, and a plant extract in separate compartments for timed release.
A tannic acid and copper coating responds to acidity, releasing copper and antibiotic fast when infection flares. Later stages free more copper to grow blood vessels, then steady doses to prevent infection returning and rebuild bone. Immune cells shifted from attack mode toward repair mode under treatment. In animal defects the spheres cleared infection and sped vascularised bone regrowth.
Catalog record
| CREATOR | Dongbiao Chang, Zhenfan Bai, Linke Li, Jun Sheng, Hongzhi Fang, Zian Wang, Zili Guo, Hui Zhang, Xinxi Yang, Rui Chen, Huan Tan, Mengyuan Wang, Jie Weng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 74 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |