Developmental oligodendrocytes regulate brain function through the mediation of synchronized spontaneous activity
Ryo Masumura, Kyosuke Goda, Mariko Sekiguchi, Naofumi Uesaka, K VijayRaghavan, Ryo Masumura, Kyosuke Goda, Mariko Sekiguchi, Naofumi Uesaka · 2026
Read Developmental oligodendrocytes regulate brain function through the mediation of synchronized spontaneous activity by Ryo Masumura, Kyosuke Goda, Mariko Sekiguchi, Naofumi Uesaka, K VijayRaghavan, Ryo Masumura, Kyosuke Goda, Mariko Sekiguchi, Naofumi Uesaka (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13278736.txt.
Description
Ryo Masumura leads a 2026 mouse study showing that cells called oligodendrocytes help organize early brain activity. These cells coat nerve fibers in the brain. Young brains show waves of activity in sync across cells, and that sync is thought to guide wiring. The team used gene tools in the cerebellum to remove the coating cells at set ages.
Loss in the first days of life, but not after weaning, broke the sync of Purkinje cell activity, both in pups and in adults. Lasting gaps followed in anxiety, social behavior, and movement. Restoring sync in adults with light-based tools rescued movement and social function, but not anxiety. Early support cells shape lifelong brain function through the activity patterns they enable.
Catalog record
| CREATOR | Ryo Masumura, Kyosuke Goda, Mariko Sekiguchi, Naofumi Uesaka, K VijayRaghavan, Ryo Masumura, Kyosuke Goda, Mariko Sekiguchi, Naofumi Uesaka |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 85894 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |