HMMR as a robust prognostic biomarker correlates with immune infiltration and cell cycle pathways in oral squamous cell carcinoma: a multi-cohort bioinformatics analysis based on TCGA and GEO databases
Lingling Liu, Shiyan Chen, Hongxun Gong, Xingfeng Qi, Maoxin Wang · 2026
Read HMMR as a robust prognostic biomarker correlates with immune infiltration and cell cycle pathways in oral squamous cell carcinoma: a multi-cohort bioinformatics analysis based on TCGA and GEO databases by Lingling Liu, Shiyan Chen, Hongxun Gong, Xingfeng Qi, Maoxin Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13278685.txt.
Description
Lingling Liu and colleagues examine a cell-movement gene, HMMR, as a marker in oral squamous cell carcinoma, in a 2026 analysis. This common head and neck cancer carries a poor outlook and complex biology. Public tumour datasets from TCGA and two GEO cohorts were combined for the search.
Thousands of altered genes were found, and 245 were shared across all three datasets. Three genes showed prognostic promise, with HMMR giving the strongest prediction scores. Tumours with high HMMR sat at more advanced stages and patients fared worse on survival measures. HMMR also tracked with several immune cell types inside tumours, especially helper T cell groups. The authors propose it as an independent prognostic marker.
Catalog record
| CREATOR | Lingling Liu, Shiyan Chen, Hongxun Gong, Xingfeng Qi, Maoxin Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |