Dynamic Changes in Midbrain–Striatal Association and Their Relationship With Levodopa‐Induced Dyskinesia in Parkinson’s Disease
Eun Hye Jeong, Jae Yong Lee, Hyun Soo Park, Yoo Sung Song, Suraiya Saleem · 2026
Read Dynamic Changes in Midbrain–Striatal Association and Their Relationship With Levodopa‐Induced Dyskinesia in Parkinson’s Disease by Eun Hye Jeong, Jae Yong Lee, Hyun Soo Park, Yoo Sung Song, Suraiya Saleem (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13277766.txt.
Description
Eun Hye Jeong leads a 2026 study of brain imaging changes tied to levodopa-induced dyskinesia, the involuntary movements that can follow long treatment for Parkinson's disease. The cause of this side effect is unclear. The team followed 169 patients who had never taken Parkinson's drugs, using an existing database and scans over four years.
Patients who developed the movements started with lower binding signals in movement-related brain areas and lost signal faster, above all in the putamen. Midbrain signals, read as a proxy for a broader chemical messenger system, held up relatively early on. Dose of levodopa did not explain the coupling pattern. The movements may mark a faster-declining form of the disease, the authors suggest.
Catalog record
| CREATOR | Eun Hye Jeong, Jae Yong Lee, Hyun Soo Park, Yoo Sung Song, Suraiya Saleem |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38233 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |