Platelet-Targeted Self-Amplifying mRNA for Safe, Long-Acting Thromboprophylaxis
Yuyang Song, Thanh Hung Nguyen, Pengkai Shi, Ahmed Refaat, Cuong Viet Pham, Bangyan Xu, Shulei Ren, Julia I. Skoraczynski, Anne Nguyen, Haikun Liu, Alexander Klesen, Sylvain Trépout, Mark Louis P. Vidallon, Karlheinz Peter, Xiaowei Wang · 2026
Read Platelet-Targeted Self-Amplifying mRNA for Safe, Long-Acting Thromboprophylaxis by Yuyang Song, Thanh Hung Nguyen, Pengkai Shi, Ahmed Refaat, Cuong Viet Pham, Bangyan Xu, Shulei Ren, Julia I. Skoraczynski, Anne Nguyen, Haikun Liu, Alexander Klesen, Sylvain Trépout, Mark Louis P. Vidallon, Karlheinz Peter, Xiaowei Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13277727.txt.
Description
Yuyang Song and co-authors test a gene-based way to stop blood clots without raising bleed risk in a 2026 study. Standard anti-clot drugs cut clots but can cause bleeding through the whole body. The team instead builds a blocker that acts only on switched-on platelets, the cell bits that start clots.
The blocker was coded into two kinds of messenger RNA and packed for delivery in the body. In mice with forced artery clots, one dose delayed blockage for a day, and the self-copying form guarded for more than a week. Bleed times stayed normal, with no signs of organ harm. Longer, safer clot guarding may follow.
Catalog record
| CREATOR | Yuyang Song, Thanh Hung Nguyen, Pengkai Shi, Ahmed Refaat, Cuong Viet Pham, Bangyan Xu, Shulei Ren, Julia I. Skoraczynski, Anne Nguyen, Haikun Liu, Alexander Klesen, Sylvain Trépout, Mark Louis P. Vidallon, Karlheinz Peter, Xiaowei Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |