Myelin debris uptake by macrophages and microglia: Resolution of foam cells with a series of novel cyclodextrins
Emily C Wuerch, Charbel S Baaklini, Ping Zhang, Marlene T Mørch, Austin Che, Charlotte D'Mello, Chang-Chun Ling, V Wee Yong · 2026
Read Myelin debris uptake by macrophages and microglia: Resolution of foam cells with a series of novel cyclodextrins by Emily C Wuerch, Charbel S Baaklini, Ping Zhang, Marlene T Mørch, Austin Che, Charlotte D'Mello, Chang-Chun Ling, V Wee Yong (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13277444.txt.
Description
Emily C Wuerch leads a 2026 laboratory study of foamy immune cells in multiple sclerosis, a disease where the fatty coating on nerve fibers is damaged. Macrophages and microglia, immune cells that eat debris, can overload on that coating and turn inflammatory, blocking repair. The team built a lab model of these foamy cells using human and mouse cells.
Long exposure to myelin debris plus inflammatory signals gave the cells an MS-like gene pattern. Ring-shaped sugar compounds called cyclodextrins then cut the stored fat in some cells and shifted genes tied to inflammation and healing. The compounds may calm this cell type, the authors suggest, but far more work is needed before any treatment claim.
Catalog record
| CREATOR | Emily C Wuerch, Charbel S Baaklini, Ping Zhang, Marlene T Mørch, Austin Che, Charlotte D'Mello, Chang-Chun Ling, V Wee Yong |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61808 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |