LPLAT7 reutilizes unsaturated 1-lysophospholipids formed during lysosomal phospholipid degradation
Yang Xu, Sujith Rajan, Colin K.L. Phoon, Mindong Ren, M. Mahmood Hussain, Michael Schlame · 2026
Read LPLAT7 reutilizes unsaturated 1-lysophospholipids formed during lysosomal phospholipid degradation by Yang Xu, Sujith Rajan, Colin K.L. Phoon, Mindong Ren, M. Mahmood Hussain, Michael Schlame (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13277423.txt.
Description
Xu, Rajan, Phoon, Ren, Hussain, and Schlame study how an enzyme recycles lysosome products in twenty twenty-six. Lysosomes break down phospholipids from cell membranes. That breakdown yields fragments that can be degraded or reused. One fragment type carries an unsaturated fatty acid chain.
The enzyme LPLAT7 sits in the endoplasmic reticulum and reacylates those fragments. It acts specifically on the lysosome derived, unsaturated forms. Knocking it out in liver cells blocked reuse of fragments from labelled phospholipids. In mice, knockout raised unsaturated fragment levels and cut key membrane lipids. Membrane regeneration slowed, and fat droplets accumulated instead. The authors say the enzyme shifts lipid flow from droplets toward membranes.
Catalog record
| CREATOR | Yang Xu, Sujith Rajan, Colin K.L. Phoon, Mindong Ren, M. Mahmood Hussain, Michael Schlame |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |