Structure, characterisation and application of an unspecific peroxygenase from Daldinia childiae
Alexander McKenzie, Claudia Clark, Katy A. S. Cornish, Jiacheng Li, Jack Domenech, Benjamin Melling, Miles P. H. Ralston, Jared Cartwright, Nicholas P. Mulholland, William P. Unsworth, Gideon Grogan · 2026
Read Structure, characterisation and application of an unspecific peroxygenase from Daldinia childiae by Alexander McKenzie, Claudia Clark, Katy A. S. Cornish, Jiacheng Li, Jack Domenech, Benjamin Melling, Miles P. H. Ralston, Jared Cartwright, Nicholas P. Mulholland, William P. Unsworth, Gideon Grogan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13277406.txt.
Description
Alexander McKenzie leads a 2026 study of an enzyme from a fungus, Daldinia childiae, that can add oxygen to other molecules. Such enzymes, called unspecific peroxygenases, are valued as green catalysts for making chemicals with precision. The team produced the enzyme in two host systems and mapped its three-dimensional structure.
The structure showed a differently shaped active tunnel from a well-known relative enzyme. That difference changed which products the enzyme made. For example, it turned menthol into one specific alcohol product, while its relative gave a different one exclusively. Small structural changes can redirect these catalysts, the work shows, which matters for designing enzymes for drug and chemical making.
Catalog record
| CREATOR | Alexander McKenzie, Claudia Clark, Katy A. S. Cornish, Jiacheng Li, Jack Domenech, Benjamin Melling, Miles P. H. Ralston, Jared Cartwright, Nicholas P. Mulholland, William P. Unsworth, Gideon Grogan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 21192 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |