Divided-and-combined association test for pleiotropic effects with GWAS summary statistics
Boheng Hu, Yaoyao Chen, Xueqin Zheng, Hongping Guo · 2026
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Description
A split-and-join test for genes that sway many traits is built by Boheng Hu and co-authors in work dated 2026. Past gene scans test one trait at a time and miss such shared effects. Summary stats from old scans now allow joint tests. The new test blends a family of square-form stats, each weighted its own way. Blend weights ride on trait ties and gene ties at once.
Fake tests hold false calls in check and top power in most scenes. On four heart and vessel ills, the test found more genes than four rival tools. Shared-cause hunts gain a sharper net.
Catalog record
| CREATOR | Boheng Hu, Yaoyao Chen, Xueqin Zheng, Hongping Guo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 178 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |