GD3s-mediated lipid metabolism reprograming promotes proliferation and metastasis of melanoma
Jinyi Liu, Xiaoxue Li, Wan Li, Hong Yang, Xiangjin Zheng, Sha Li, Yihui Yang, Yizhi Zhang, Guanhua Du, Yumin Wang, Jinhua Wang · 2026
Read GD3s-mediated lipid metabolism reprograming promotes proliferation and metastasis of melanoma by Jinyi Liu, Xiaoxue Li, Wan Li, Hong Yang, Xiangjin Zheng, Sha Li, Yihui Yang, Yizhi Zhang, Guanhua Du, Yumin Wang, Jinhua Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13277071.txt.
Description
Jinyi Liu and colleagues traced a fat-making enzyme in melanoma in 2026. Melanoma is aggressive and increasingly common. A surface sugar lipid marks melanoma cells. Its synthase enzyme limits production speed. Function of that synthase stayed poorly understood. Cell and animal methods probed it directly.
Silencing the synthase slowed tumour behaviour. New fat production fell after silencing. A signalling pathway carried that effect. One drug compound blocked the synthase newly. Tumour effects looked good in dishes. Animal tests also showed benefit. Lipid rewiring drives melanoma progression here. A new drug target emerges clearly.
Catalog record
| CREATOR | Jinyi Liu, Xiaoxue Li, Wan Li, Hong Yang, Xiangjin Zheng, Sha Li, Yihui Yang, Yizhi Zhang, Guanhua Du, Yumin Wang, Jinhua Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |