Targeting lysosomal pH restores mitochondrial quality control in GBA1-mutant Parkinson’s disease
Preethi Sheshadri, Maria Alicia Costa-Besada, Alessia Fisher, Szilvia Kiraly, Kritarth Singh, Ioanna Kourouzidou, Thomas S. Blacker, Jialiu Zeng, Orian S. Shirihai, Mark W. Grinstaff, Michael R. Duchen · 2026
Read Targeting lysosomal pH restores mitochondrial quality control in GBA1-mutant Parkinson’s disease by Preethi Sheshadri, Maria Alicia Costa-Besada, Alessia Fisher, Szilvia Kiraly, Kritarth Singh, Ioanna Kourouzidou, Thomas S. Blacker, Jialiu Zeng, Orian S. Shirihai, Mark W. Grinstaff, Michael R. Duchen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13277009.txt.
Description
Preethi Sheshadri leads a 2026 cell study of Parkinson's disease linked to changes in a gene called GBA1. The gene helps lysosomes, the cell parts that break down waste, stay acidic enough to work. The team grew nerve cells from patient stem cells and measured waste cleanup and energy production.
Mutant nerve cells had weak lysosome acidity, poor cleanup of worn-out mitochondria, the cell's energy makers, and low energy output. A faulty pump that should acidify lysosomes sat behind the problem. Two treatments, rapamycin and acidic nanoparticles, restored acidity and rescued energy function. The authors present that repair route as a possible new treatment direction for this form of Parkinson's.
Catalog record
| CREATOR | Preethi Sheshadri, Maria Alicia Costa-Besada, Alessia Fisher, Szilvia Kiraly, Kritarth Singh, Ioanna Kourouzidou, Thomas S. Blacker, Jialiu Zeng, Orian S. Shirihai, Mark W. Grinstaff, Michael R. Duchen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 77926 |
| LICENSE | https://creativecommons.org/publicdomain/zero/1.0 |
| RIGHTS | CC0 |
| SOURCE | Europe PMC |