Amoxicillin Direct Oral Challenge in Hospitalized Patients With High-Risk Allergic Reactions, in a Pharmacist-Directed Program
Bryan Le, Shyam Joshi, Kendall Tucker, Young Yoon Ham · 2026
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Description
Bryan Le, Shyam Joshi, Kendall Tucker, and Young Yoon Ham report a pharmacist-led penicillin allergy programme in a 2026 paper. Millions carry penicillin allergy labels, yet most can actually tolerate the drug safely. False labels push doctors toward costlier antibiotics with more side effects.
The programme offered a direct oral dose of amoxicillin to hospital patients whose reported reactions were at least ten years old. Reported histories included hives, swelling, anaphylaxis, and breathlessness. Of 169 patients challenged, the great majority tolerated the dose and had the label removed. Mild reactions occurred in a small share, with no severe events, which supports wider use of this simpler route.
Catalog record
| CREATOR | Bryan Le, Shyam Joshi, Kendall Tucker, Young Yoon Ham |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 16 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |