Label-Free Raman Spectroscopy Reveals Metabolic Signatures Associated with MGMT Promoter Methylation Status in Glioblastoma
Dou Lu, Lijun Zhu, Jing Pan, Jianrui Li, Qing Xu, Liying Wang, Qing-Qing Zhou, Hao Pan, Qiang Wang, Dong Han, Zhiqiang Zhang, Jingxing Guo, Xiaoqing Cheng, Yiqing Wang, Huiming Cai, Xiaoyuan Chen, Longjiang Zhang, Guangming Lu · 2026
Read Label-Free Raman Spectroscopy Reveals Metabolic Signatures Associated with MGMT Promoter Methylation Status in Glioblastoma by Dou Lu, Lijun Zhu, Jing Pan, Jianrui Li, Qing Xu, Liying Wang, Qing-Qing Zhou, Hao Pan, Qiang Wang, Dong Han, Zhiqiang Zhang, Jingxing Guo, Xiaoqing Cheng, Yiqing Wang, Huiming Cai, Xiaoyuan Chen, Longjiang Zhang, Guangming Lu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13276842.txt.
Description
Dou Lu and a large team use laser light tests to read tumour signals in glioblastoma, in a 2026 study. Response to the standard drug temozolomide hinges on whether a gene called MGMT is silenced by methylation. Current tests reveal methylation but give no clues for drug design.
Gene-edited cell models with set methylation states gave clean reference patterns. Methylated cells showed more saturated fat signal, while unmethylated cells showed stronger DNA, amino acid, and unsaturated fat signals. Chemical analysis confirmed the light-based findings before the team built a sorting model. On sixty-two patient samples the model separated methylation states well, suggesting metabolic routes against drug resistance.
Catalog record
| CREATOR | Dou Lu, Lijun Zhu, Jing Pan, Jianrui Li, Qing Xu, Liying Wang, Qing-Qing Zhou, Hao Pan, Qiang Wang, Dong Han, Zhiqiang Zhang, Jingxing Guo, Xiaoqing Cheng, Yiqing Wang, Huiming Cai, Xiaoyuan Chen, Longjiang Zhang, Guangming Lu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |