Design, synthesis, and biological evaluation of 6-aryl-3-(3,4,5-trimethoxyphenyl)imidazo[1,2-a]pyridine derivatives as novel tubulin inhibitors with potent anticancer efficacy
Wen Xu, Yujing Zhang, Qianqian Xu, Haibo Zhao, Liya Cui, Chao Wang · 2026
Read Design, synthesis, and biological evaluation of 6-aryl-3-(3,4,5-trimethoxyphenyl)imidazo[1,2-a]pyridine derivatives as novel tubulin inhibitors with potent anticancer efficacy by Wen Xu, Yujing Zhang, Qianqian Xu, Haibo Zhao, Liya Cui, Chao Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13276812.txt.
Description
Wen Xu leads a 2026 laboratory study that designs new compounds against cancer. The compounds aim at tubulin, a protein that helps cells divide, and try to block its assembly. The team built a focused set of molecules in the lab and tested them on human cancer cells grown in dishes.
One compound, labeled 8o, slowed growth in cervical, colon, and breast cancer cell lines at very low doses. It broke up the cell skeleton, halted division, and triggered cell death. Early checks also suggested it fits common rules for drug-like compounds. The work is still at the cell stage, so animal and human tests would come next if it holds up.
Catalog record
| CREATOR | Wen Xu, Yujing Zhang, Qianqian Xu, Haibo Zhao, Liya Cui, Chao Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59859 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |