The relation between observer-rated depressive symptoms and patient-rated quality of life after six weeks of antidepressant treatment: pooled patient-level analysis of mirtazapine trials
Helena Werin Sjögren, Evana López, Alexander Lisinski, Mikael Landén, Johan Lundberg, Fredrik Hieronymus · 2026
Read The relation between observer-rated depressive symptoms and patient-rated quality of life after six weeks of antidepressant treatment: pooled patient-level analysis of mirtazapine trials by Helena Werin Sjögren, Evana López, Alexander Lisinski, Mikael Landén, Johan Lundberg, Fredrik Hieronymus (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13276756.txt.
Description
Helena Werin Sjögren and colleagues pool depression trial data to test whether symptom scores match patients' own life quality ratings, in a 2026 analysis. Trials usually judge antidepressants by clinician-rated scales such as the Hamilton scale. Critics say those scales may miss what patients themselves feel has improved.
Six trials comparing mirtazapine with other antidepressants supplied data on 918 patients over six weeks. Quality-of-life scores tracked the clinician scale closely, especially its mood and work items. Patients judged in remission reported life quality near the low end of healthy ranges. Those with even mild remaining symptoms rated their lives as severely impaired, underlining the value of full remission.
Catalog record
| CREATOR | Helena Werin Sjögren, Evana López, Alexander Lisinski, Mikael Landén, Johan Lundberg, Fredrik Hieronymus |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |