Modeling cancer with bacteria-integrated tumor microenvironments using biomaterials: Emerging concepts and opportunities
Keuna Jeon, Uijin Kim, Chang-Hun Ji, Meenakshi Kamaraj, Noah Zachary Laird, Zhikun Wang, Hongxiao Yu, Menekse Ermis, Ruby May A Sullan, Xiling Shen, Natashya Falcone · 2026
Read Modeling cancer with bacteria-integrated tumor microenvironments using biomaterials: Emerging concepts and opportunities by Keuna Jeon, Uijin Kim, Chang-Hun Ji, Meenakshi Kamaraj, Noah Zachary Laird, Zhikun Wang, Hongxiao Yu, Menekse Ermis, Ruby May A Sullan, Xiling Shen, Natashya Falcone (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13276601.txt.
Description
Keuna Jeon and co-authors propose a new way to model tumours together with their bacteria, in a 2026 concept article. Bacteria living inside tumours can shape metabolism, immune behaviour, and treatment response. Lab models rarely include those microbes, so a whole layer of tumour biology goes untested.
The authors lay out design rules for engineered tumour tissues that host bacteria in set places. Oxygen and nutrient gradients, plus signals between human and bacterial cells, need deliberate control. Planned uses include studying drug resistance, testing engineered bacterial therapies, and building patient-specific models. They also flag standardisation and measurement hurdles that the field must solve before such models spread.
Catalog record
| CREATOR | Keuna Jeon, Uijin Kim, Chang-Hun Ji, Meenakshi Kamaraj, Noah Zachary Laird, Zhikun Wang, Hongxiao Yu, Menekse Ermis, Ruby May A Sullan, Xiling Shen, Natashya Falcone |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 90 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |