SM03, a non-depleting anti-CD22 antibody, modulates B cell activation and immune crosstalk to attenuate autoimmunity
Kin Lok Wong, Lung Hei Cheng, Cheuk Ling Chung, Pui Lam Ng, Shaik Abdullah Nawabjan, Muthu Iswarya Gandhi Sethuraman, Ka Kiu Luk, Wing Tung Tsoi, Billy Kwok Chong Chow, Shui On Leung · 2026
Read SM03, a non-depleting anti-CD22 antibody, modulates B cell activation and immune crosstalk to attenuate autoimmunity by Kin Lok Wong, Lung Hei Cheng, Cheuk Ling Chung, Pui Lam Ng, Shaik Abdullah Nawabjan, Muthu Iswarya Gandhi Sethuraman, Ka Kiu Luk, Wing Tung Tsoi, Billy Kwok Chong Chow, Shui On Leung (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13276457.txt.
Description
Kin Lok Wong and co-authors present a 2026 journal article on an antibody drug that calms overactive B cells in autoimmune disease. In lupus and rheumatoid arthritis, B cells help attack the body's own tissues. Most B cell drugs wipe the cells out; this one, SM03, instead strengthens a natural brake on them, a surface protein called CD22.
In lab tests with cells from healthy donors and patients, the drug cut B cell activation, antibody-producing cell formation, and inflammatory signals, all without killing B cells. In a lupus-like mouse model it shrank the spleen, lowered self-attacking antibodies, and reduced kidney damage signs. In monkeys with induced arthritis it eased joint scores and cartilage damage dose by dose. The authors call it a disease-modifying candidate for lupus, arthritis, and related conditions.
Catalog record
| CREATOR | Kin Lok Wong, Lung Hei Cheng, Cheuk Ling Chung, Pui Lam Ng, Shaik Abdullah Nawabjan, Muthu Iswarya Gandhi Sethuraman, Ka Kiu Luk, Wing Tung Tsoi, Billy Kwok Chong Chow, Shui On Leung |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59766 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |