Cannabis and Psychosis: Genomic Methods Shed Light on Pathophysiological Processes
Jack FG Underwood, Jeremy Hall · 2026
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Description
Jack Underwood and Jeremy Hall wrote a 2026 commentary on what genetics can reveal about cannabis and psychosis. A decade ago, reviewers found evidence strong enough for a public health warning that cannabis raises psychosis risk. Whether cannabis directly causes psychosis, or shared genes drive both, stayed unresolved because good genetic tools were lacking.
The commentary discusses a new genomic study of cannabis use disorder and psychosis by a large team. That study deploys several genetic methods that were impractical ten years ago. One technique estimates direct genetic effects while accounting for a linked trait. Another groups gene variants by shared effect directions, hunting for biological pathways. The authors frame these approaches as a way to move from association toward mechanism, and to test whether some people's genes make them more vulnerable to cannabis-linked psychosis.
Catalog record
| CREATOR | Jack FG Underwood, Jeremy Hall |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 9455 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |