Hyaluronic acid and folic acid-modified mesoporous silica nanoparticles delivering sulforaphane suppress NSCLC via SPI1/miR-616-5p axis
Wujin Li, Changjian Lin, Hang Xu, Wenxiang Yue, Yi Xu, Baosong Xie, Daxuan Wang · 2026
Read Hyaluronic acid and folic acid-modified mesoporous silica nanoparticles delivering sulforaphane suppress NSCLC via SPI1/miR-616-5p axis by Wujin Li, Changjian Lin, Hang Xu, Wenxiang Yue, Yi Xu, Baosong Xie, Daxuan Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13276326.txt.
Description
Wujin Li and co-authors present a 2026 journal article on stopping lung cancer spread with a broccoli compound delivered in nanoparticles. Sulforaphane, found in cruciferous vegetables, can slow metastasis, the spread of cancer, but it breaks down too easily for clinic use. The team traced how it works in non-small cell lung cancer.
They found a gene switch called SPI1 turns up a small RNA that drives cancer cells to invade and migrate. Sulforaphane binds the switch directly and quiets the small RNA, blunting spread. To protect the fragile compound, the team loaded it into porous silica nanoparticles coated with two targeting molecules. The particles stayed stable, entered tumor cells well, and homed to tumors. In mouse models they fought metastasis better than the free compound. The authors see clinical potential in the delivery system.
Catalog record
| CREATOR | Wujin Li, Changjian Lin, Hang Xu, Wenxiang Yue, Yi Xu, Baosong Xie, Daxuan Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60731 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |