MFAP5+ synovial fibroblasts drive LOX upregulation to promote osteoarthritis progression
Linzhu Wang, Guozhao Wei, Fenghua Ma, Xingyu Li, Huizhen Zhang, Houliang Pan, Zikang Meng, Sen Yang, Ruonan Yang, Juan Dong, Xue Xiong, Zhaoyuan Xu, Boyang Zhang, Hongyi Cheng, Baiyan Li, Lei Yang, Xiaoqiang E, Xuelian Li · 2026
Read MFAP5+ synovial fibroblasts drive LOX upregulation to promote osteoarthritis progression by Linzhu Wang, Guozhao Wei, Fenghua Ma, Xingyu Li, Huizhen Zhang, Houliang Pan, Zikang Meng, Sen Yang, Ruonan Yang, Juan Dong, Xue Xiong, Zhaoyuan Xu, Boyang Zhang, Hongyi Cheng, Baiyan Li, Lei Yang, Xiaoqiang E, Xuelian Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13276305.txt.
Description
Linzhu Wang and co-authors report a 2026 journal article on a cell type that may drive osteoarthritis toward its end stage. Osteoarthritis wears down joints and has no approved drug that stops it. The synovium, the joint's inner lining, is packed with fibroblast cells whose changes were unclear.
Gene profiling showed a fibroblast group marked by a protein called MFAP5 flooding late-stage diseased joints. Staining confirmed the protein was far higher in late-stage human and rat tissue than in early disease or healthy joints. These cells also made large amounts of LOX, an enzyme that stiffens tissue. Silencing MFAP5 cut the LOX rise in rat cells, and adding MFAP5 boosted it. A drug blocking LOX eased joint damage in rats with the disease. The authors propose this pathway as a treatment target.
Catalog record
| CREATOR | Linzhu Wang, Guozhao Wei, Fenghua Ma, Xingyu Li, Huizhen Zhang, Houliang Pan, Zikang Meng, Sen Yang, Ruonan Yang, Juan Dong, Xue Xiong, Zhaoyuan Xu, Boyang Zhang, Hongyi Cheng, Baiyan Li, Lei Yang, Xiaoqiang E, Xuelian Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58976 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |