In Vitro hRPTEC TERT1 Model for Uranium‐Induced Nephrotoxicity Pathway Study
Marie Frerejacques, Victoria Powell, Sebastien Giraud, Annabelle Manoury, Céline Bouvier-Capely, Thierry Hauet, Clara Steichen, Yann Guéguen · 2026
Read In Vitro hRPTEC TERT1 Model for Uranium‐Induced Nephrotoxicity Pathway Study by Marie Frerejacques, Victoria Powell, Sebastien Giraud, Annabelle Manoury, Céline Bouvier-Capely, Thierry Hauet, Clara Steichen, Yann Guéguen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13276292.txt.
Description
Marie Frerejacques and co-authors present a 2026 journal article on how uranium harms the kidney, studied in lab-grown human kidney cells. Uranium is both a heavy metal and a weak radiation source, and the kidney is its main target. The team used a cell line that mimics the kidney tubules where damage starts.
Cells were exposed to rising uranium doses for two days. Cell death by self-destruction began at moderate doses, and outright cell rupture at higher ones. Half the cells died at a mid-range concentration the team identified. Uranium quickly doubled the production of reactive oxygen, unstable molecules that damage cells. Survival signals rose at low doses, but higher doses triggered strong inflammation signals. A known kidney injury marker rose slightly at the top dose. The panel of events feeds a safety framework for uranium poisoning.
Catalog record
| CREATOR | Marie Frerejacques, Victoria Powell, Sebastien Giraud, Annabelle Manoury, Céline Bouvier-Capely, Thierry Hauet, Clara Steichen, Yann Guéguen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47199 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |