Inflammatory cytokine IL‐6 regulates ADAMTS14 expression through MAPK and PI3K signaling in colorectal cancer
Nelin Hacioglu, Rümeysa Nur Vapur Ondul, Ghufran Haqi Ismael, Feray Kockar · 2026
Read Inflammatory cytokine IL‐6 regulates ADAMTS14 expression through MAPK and PI3K signaling in colorectal cancer by Nelin Hacioglu, Rümeysa Nur Vapur Ondul, Ghufran Haqi Ismael, Feray Kockar (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13276287.txt.
Description
Nelin Hacioglu and co-authors present a 2026 journal article on how inflammation may switch on a gene in colorectal cancer. The gene, ADAMTS14, codes for an enzyme that reshapes the matrix holding cells together. How inflammation controls it was poorly understood.
Treating cancer cells with interleukin-6, a key inflammation signal, raised the gene's activity at both message and protein levels. Cutting down the gene's control region pinpointed the stretch that responds to the signal. Blocking several known signaling routes blunted the response. In large public tumor datasets, the gene ran high in tumors and tracked with inflammation, scar-like tissue activity, and matrix-building programs. The authors suggest inflammation helps reorganize the tissue around tumors partly through this gene.
Catalog record
| CREATOR | Nelin Hacioglu, Rümeysa Nur Vapur Ondul, Ghufran Haqi Ismael, Feray Kockar |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47906 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |