CD59 drives diet-induced obesity and glucose intolerance, insulin resistance, and metabolic dysfunction-associated steatotic liver disease
Marian Zeibak, Netanel Karbian, Yael Riahi, Saja Baraghithy, Labiba Ahmad, Adi Tabib, Ifat Abromovitz, Bella Agranovitz, Hadar Benyamini, Eyal Gottlieb, Joseph Tam, Yuval Dor, Gil Leibowitz, Dror Mevorach · 2026
Read CD59 drives diet-induced obesity and glucose intolerance, insulin resistance, and metabolic dysfunction-associated steatotic liver disease by Marian Zeibak, Netanel Karbian, Yael Riahi, Saja Baraghithy, Labiba Ahmad, Adi Tabib, Ifat Abromovitz, Bella Agranovitz, Hadar Benyamini, Eyal Gottlieb, Joseph Tam, Yuval Dor, Gil Leibowitz, Dror Mevorach (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13276272.txt.
Description
Marian Zeibak and co-authors present a 2026 journal article on a surprising driver of obesity and diabetes in mice. The protein, CD59, sits on cell surfaces and normally shields cells from the complement system, part of the immune defenses. Its role in metabolism had not been explored.
Mice missing the mouse version of this protein were fed a high-fat diet. Unlike normal mice, they were protected from obesity, fatty liver, and insulin resistance, the core defect in type 2 diabetes. Their blood sugar control stayed better and their insulin stayed lower. Cage studies suggested they ate less and moved more on running wheels. Liver gene readings showed far less inflammation and scarring activity. The authors say this immune protein plays an unexpected part in diet-driven metabolic disease.
Catalog record
| CREATOR | Marian Zeibak, Netanel Karbian, Yael Riahi, Saja Baraghithy, Labiba Ahmad, Adi Tabib, Ifat Abromovitz, Bella Agranovitz, Hadar Benyamini, Eyal Gottlieb, Joseph Tam, Yuval Dor, Gil Leibowitz, Dror Mevorach |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60494 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |