15-LOX-catalytic bias towards ether-(alkenyl)-ETE-PEs oxidation bestows selectivity of PRO-ferroptotic cell death signaling
Yulia Y Tyurina, Karolina Mikulska-Ruminska, Vladimir A Tyurin, Brian A Kleiboeker, Alexander A Kapralov, Ayumi Hashimoto, Louis J Sparvero, Haider H Dar, Mert Akdogan, Kazuhiro Yamada, Jinming Zhao, Taha Kelestemur, Ecem Saritas, Sviatlana N Samovich, Theodore R Holman, Yuri L Bunimovich, Yulia Nefedova, Dmitry I Gabrilovich, Sally E Wenzel, Ivet Bahar, Valerian E Kagan, Hülya Bayır · 2026
Read 15-LOX-catalytic bias towards ether-(alkenyl)-ETE-PEs oxidation bestows selectivity of PRO-ferroptotic cell death signaling by Yulia Y Tyurina, Karolina Mikulska-Ruminska, Vladimir A Tyurin, Brian A Kleiboeker, Alexander A Kapralov, Ayumi Hashimoto, Louis J Sparvero, Haider H Dar, Mert Akdogan, Kazuhiro Yamada, Jinming Zhao, Taha Kelestemur, Ecem Saritas, Sviatlana N Samovich, Theodore R Holman, Yuri L Bunimovich, Yulia Nefedova, Dmitry I Gabrilovich, Sally E Wenzel, Ivet Bahar, Valerian E Kagan, Hülya Bayır (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13276253.txt.
Description
Yulia Tyurina and co-authors present a 2026 journal article on which membrane fats feed a type of cell death called ferroptosis. In ferroptosis, iron drives damage to fatty molecules until the cell dies. One fat family, the ether lipids, was thought to protect against this death, but the evidence was mixed.
Using detailed fat analysis, lab tests, gene tools, and computer models, the team studied an enzyme called 15-LOX. Both forms of the enzyme eagerly oxidized one class of ether fat, turning it into a death signal. The step once thought protective ran about five hundred times slower, ruling it out here. The death signal also appeared as a harmful factor in asthma, cancer, brain trauma, and sunburn-like skin injury. The authors name the enzyme's bias as a possible drug target.
Catalog record
| CREATOR | Yulia Y Tyurina, Karolina Mikulska-Ruminska, Vladimir A Tyurin, Brian A Kleiboeker, Alexander A Kapralov, Ayumi Hashimoto, Louis J Sparvero, Haider H Dar, Mert Akdogan, Kazuhiro Yamada, Jinming Zhao, Taha Kelestemur, Ecem Saritas, Sviatlana N Samovich, Theodore R Holman, Yuri L Bunimovich, Yulia Nefedova, Dmitry I Gabrilovich, Sally E Wenzel, Ivet Bahar, Valerian E Kagan, Hülya Bayır |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 113454 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |